| Type | Date | Time | Venue | Away | Home | Score |
|---|---|---|---|---|---|---|
| Fri Mar 31 | 4:00 pm | Northwest Regional Park - Grass | Pittsburgh | South Carolina | 9 - 6 | |
| Fri Mar 31 | 5:00 pm | Northwest Regional Park - Turf | Boston College | Virginia Tech | 5 - 9 | |
| Fri Mar 31 | 5:00 pm | Kittredge Field | Georgia Tech | Colorado | 13 - 18 | |
| Fri Mar 31 | 7:00 pm | Alabama West Quad #8 | Ole Miss | Alabama | 7 - 12 | |
| Fri Mar 31 | 7:00 pm | Georgia Club Sports Complex | Auburn | Georgia | 10 - 9 | |
| Fri Mar 31 | 7:00 pm | Northwest Regional Park - Turf | Purdue | NC State | 6 - 13 | |
| Fri Mar 31 | 8:00 pm | Liberty Men's Lacrosse Field | Florida State | Liberty | 7 - 11 | |
| Fri Mar 31 | 8:00 pm | Greenbrier | George Washington | West Virginia | 13 - 3 | |
| Fri Mar 31 | 8:00 pm | Northwest Regional Park - Grass | Indiana | Elon | 5 - 4 | |
| Fri Mar 31 | 8:30 pm | Clemson Rec Sports Fields | East Carolina | Clemson | 7 - 13 |
Legend
- Divisional Game
- Out
- Playoff Game
- Scrimmage
- Tournament Game
- Active
- Cancelled Game
- Forfeit
- Live
- No Contest
- Postponed
- Rescheduled Game