| Type | Date | Time | Venue | Away | Home | Score |
|---|---|---|---|---|---|---|
| Sat Feb 22 | 12:00 pm | Concordia University | Clemson | Concordia | 11 - 15 | |
| Sat Feb 22 | 1:00 pm | University of Mississippi | Arkansas | Tennessee | 9 - 10 | |
| Sat Feb 22 | 2:00 pm | WVU Rec Center | Virginia Tech | West Virginia | 13 - 10 | |
| Sat Feb 22 | 2:00 pm | Liberty Men's Lacrosse Field | Michigan State | East Carolina | 16 - 2 | |
| Sat Feb 22 | 2:00 pm | Georgia Southern University | Coastal Carolina | Florida Atlantic | 8 - 11 | |
| Sat Feb 22 | 2:00 pm | Cusabo Nation Lacrosse Complex | Appalachian State | Charleston | 5 - 16 | |
| Sat Feb 22 | 3:00 pm | Maybanks Practice Facility at Willson Field | North Florida | Citadel | 12 - 7 | |
| Sat Feb 22 | 3:00 pm | NC State - Method Road Soccer Field | Temple | NC State | 10 - 9 | |
| Sat Feb 22 | 3:00 pm | Wake Forest - Water Tower Field | Stonehill | Wake Forest | 3 - 11 | |
| Sat Feb 22 | 4:00 pm | Callaway Stadium | Purdue | Florida | 6 - 17 | |
| Sat Feb 22 | 4:00 pm | UNC Charlotte Sports Field | Kennesaw State | UNC-Charlotte | 11 - 5 | |
| Sat Feb 22 | 5:00 pm | Florida State University | South Carolina | Central Florida | 13 - 6 |
Legend
- Divisional Game
- Out
- Playoff Game
- Scrimmage
- Tournament Game
- Active
- Cancelled Game
- Forfeit
- Live
- No Contest
- Postponed
- Rescheduled Game